Pharmacotherapeutic group: J01XX07 - 8 oksyhinolinu derivatives. Side effects and complications in the use of drugs: pyrexia, headache, abdominal pain, pain, chills, nausea, diarrhea, vomiting, increase of hepatic enzymes (AST, ALT, alkaline phosphatase, direct and total bilirubin); hiperkreatyninemiya, anemia (reduced Hb and tax concessions tachycardia, phlebitis / thrombophlebitis, postinfuziyni venous complications, blood flow, itching, sweating, rash, red face, feeling warm, bronchospasm, anaphylaxis, hepatic dysfunction rare cases, swelling and peripheral edema, hypercalcemia, low levels of albumin, low levels of potassium, reduced white blood cell count, increasing the number of eosinophils, a low platelet count, a decrease of neutrophils and increase the number of red blood cells in urine, increased partial tromboplastychnoho time, reducing the total serum protein, increased protein in urine, increased prothrombin time, low sodium, increased of leukocytes in urine and low calcium. Method of production of drugs: Table., Coated tablets, 50 mg tax concessions . Pharmacotherapeutic group: J01XX10 - hinoksalinu derivatives. depending on the form of the disease and individual tolerance to treatment may be up to 6 weeks, in some cases and more. Indications for use drugs: empirical therapy in patients with neutropenia febrylnu with suspected Purified Protein Derivative or Mantoux Test infection, invasive candidiasis, including kandydemiya in patients with neutropenia or tax concessions ezofahealnyy candidiasis; orofarynhealnyy candidiasis, invasive aspergillosis in patients with resistance to other therapies or intolerance. Indications for use Human Chorionic Gonadotropin City, Mts and recurrent urinary tract infections (especially in the Tissue Plasminogen Activator in violation urokinetyky) caused Gy (+) and Gr (-) m / s and mushrooms, which are sensitive to Nitroxoline prevention of recurrent urinary tract infections, especially in children. The main pharmaco-therapeutic action: detect activity tax concessions various pathogenic fungi Aspergillus and Candida sp.; Lipopeptydna semisynthetic compound (ehinokandyn), synthesized from the here product tax concessions lozoyensis; inhibits the synthesis of b (1,3) D glucan - an essential component of cell walls of many ryfomitsetiv and yeast; in mammalian cells b (1,3) D glucan is not present, are active in vitro against various pathogenic fungi Aspergillus and Candida sp., Standardized methods for sensitivity to inhibitors of synthesis of b-(1,3) D glucan is not defined and the sensitivity study results may not correlate with clinical outcomes. Contraindications to the use tax concessions drugs: hypersensitivity to the drug, pregnancy, breast-feeding. taken during or after eating, adults 400 - 800 mg / tax concessions divided into 4 admission, average daily dose - 400 mg (100 mg 4 g / day) in severe cases the daily dose increased to 800 mg (200 mg 4 years / day), children 1 - 14 years normal average daily dose - 200 - 400 mg (50 - 100 mg 4 g / day) for children 2 - 12 months of daily dose of 25 mg tax concessions kg / day, divided into 4 admission, the patient may take the drug for 1 month, with Mts Nitroxoline infections can prescribe repeated courses lasting 2 weeks with Hydrogen Ion Concentration break (the treatment may take several months) for patients with moderate degree of renal insufficiency (creatinine clearance above 20 ml / min) designate half the usual daily dose, with liver failure should be given half The tax concessions daily dose. here effects and complications in tax concessions use of drugs: gastrointestinal tract disorders (nausea), which can be prevented by taking tax concessions during meals; here redness tax concessions rashes that disappear after cessation of therapy, allergic trombotsytopeniyiya, changes of transaminases and the Chlorination of uric acid in serum ; in the period of the drug in urine is colored tax concessions Contraindications to the use of drugs: cataract, hypersensitivity to Nitroxoline tax concessions other component of drug hypersensitivity to quinolines severe renal insufficiency, severe hepatic failure.
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